• N.Ingarsal
• S.Sivagami

A new series of 1,5-benzodiazepines were synthesised by the treatment of 1-(2-bromonaphthalen -6-yl) ethanone with substituted benzaldehydes in the presence of sodium hydroxide gave corresponding 1-(2-bromonaphthalen-6-yl)-3-arylprop-2-en-1-ones.The formed α,β-unsaturated ketones reacts with 3,4-diaminotoulene in presence of base, piperidine affords the respective 8-Methyl-2-aryl-4-(2-bromonaphthalen-6-yl)-2,3-dihydro-1H-benzo[1,5] diazepines. The synthesized compounds were characterised by IR, NMR and MASS spectral techniques. The invitro antimicrobial evaluation of synthesized benzodiazepines showed significant activities against selected microorganism.

Synthesis, Bromoacetylnaphthalene, Methylbenzodiazepine, Diaminotoluene and Antimicrobial screening.

"A New Benzodiazepine Scaffold: Synthesis, characterization and Antimicrobial Evaluation of 8-Methyl-2-aryl-4-(2-bromonaphthalen-6-yl)-2,3-dihydro-1H-benzo[1, 5]diazepines", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 7, page no.602-606, July-2018, Available :http://www.jetir.org/papers/JETIR1807547.pdf

"A New Benzodiazepine Scaffold: Synthesis, characterization and Antimicrobial Evaluation of 8-Methyl-2-aryl-4-(2-bromonaphthalen-6-yl)-2,3-dihydro-1H-benzo[1, 5]diazepines", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 7, page no. pp602-606, July-2018, Available at : http://www.jetir.org/papers/JETIR1807547.pdf