• umesh pant
• Dr. G. Gnanarajan
• Prof.(Dr.) Preeti Kothiyal

The present examination manages detailing of Tramadol hydrochloride Sustained release tables. Tramadol is a water dissolvable medication and is endorsed for three to four time multi day. Along these lines it is fundamental for the medication to build up a Sustained release dose frame with lessened danger of medication organization, reaction and patient consistence. The medication excipients similarity think about was done by Fourier Transform Infrared spectroscopy (FTIR) which uncovers no collaboration amongst tranquilize and excipients. Add up to are six batch were defined. Six detailing were set up by utilizing every polymer like Hydroxy propyl methyl cellulose (HPMC K4M) and MCCP. In the wake of settling the proportion of medication and polymer for control the arrival of medication up to wanted time. After the assessment of physical properties of tablet, the in vitro discharge think about was performed in 0.1 N HCL pH 1.2 for 8 hrs. The disintegration ponders it was obvious that the detailing (F3) indicated best and wanted medication discharge design i.e., 98.76 % in 8 hrs.

Hydroxy propyl methyl cellulose, Tramadol hydrochloride, Microcrystalline cellulose, kinetic study , stability studies.

"FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF TRAMADOL HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.792-804, August-2018, Available :http://www.jetir.org/papers/JETIR1807839.pdf

"FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLET OF TRAMADOL HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp792-804, August-2018, Available at : http://www.jetir.org/papers/JETIR1807839.pdf