• Ahmed Faraz
• S.C. Ameta
• Yogen H. Talia

In the present study, synthesis of some novel thiazole containing sulfonamide analog have been carried out. Reaction of 4-(2-{[(3-Ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl] amino}ethyl) benzenesulfonyl chloride and 3-aminoacetophenone in acetone for 36 hours afforded N-(2-{4-[(3-acetylanilino)sulfonyl]phenyl}ethyl)-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide (sulfonamide), while reaction of various aniline with hydrochloric acid yields aniline hydrochloride. Which was further reacted with ammonium thiocyanate to obtain various phenyl thioureas. To obtain thiazole, (N-(2-{4-[(3-acetylanilino)sulfonyl]phenyl}ethyl)-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide) i.e. sulfonamide was reacted with different phenyl thioureas in presence of iodine and recrystallised from methyl ethyl ketone. The synthesized compound was characterized for structural confirmation by IR, 1H NMR and elemental analysis. The antimicrobial activity of these synthesized compounds were examined by the broth dilution method. Bacterial strains such as gram-negative bacteria (Escherichia coli), and gram-positive bacteria (Staphylococcus aureus) were used.

N-(2-{4-[(3-acetylanilino)sulfonyl]phenyl}ethyl)-3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide, broth dilution method,Escherichia coli, Staphylococcus aureus

"Synthesis and Antimicrobial Evaluation of Some Novel Sulfonamide Derivatives Containing Thiazole Moiety", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.349-358, August-2018, Available :http://www.jetir.org/papers/JETIR1808046.pdf

"Synthesis and Antimicrobial Evaluation of Some Novel Sulfonamide Derivatives Containing Thiazole Moiety", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp349-358, August-2018, Available at : http://www.jetir.org/papers/JETIR1808046.pdf