• SAAMANTHI M
• Dr.S.ARUNA

ABSTRACT: The present study aims to focus on account of important chemical moiety, pyrimidine and its various derivatives acts as antimicrobial agents. Trisubstituted pyrimidine derivatives showed antibacterial and antifungal activity Nitrogen containing heterocyclic derivatives synthesized from chalcones have exhibited antiinflammatory,antioxidant, antitubercular, antibacterial activities. Then the mixture was cooled and filtered. All the compounds are purified with ethanol and m.p is noted .The novel trisubstituted pyrimidine derivatives 4a (1-24) were synthesized by urea and thiourea with different chalcones. The structure of the recrystallised compounds were confirmed by IR, 1H NMR, 13C NMR, Mass spectral analysis.

Chalcones, Urea, Thiourea , antibacterial and antifungal activity , reflux.

"SYNTHESIS AND CHARACTERIZATION OF NOVEL TRISUBSTITUTED PYRIMIDINE DERIVATIVES FROM CHALCONES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.404-407, August-2018, Available :http://www.jetir.org/papers/JETIR1808053.pdf

"SYNTHESIS AND CHARACTERIZATION OF NOVEL TRISUBSTITUTED PYRIMIDINE DERIVATIVES FROM CHALCONES ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp404-407, August-2018, Available at : http://www.jetir.org/papers/JETIR1808053.pdf