• Nirmal K. Patel
• Yogesh Baj
• Savankumar Patel

Oxidation of nicotine leads to synthesis of nicotinic acid, Nicotinic acid also known as pyridine-3-carboxylic acid or niacin, a water soluble B-complex vitamin found in various plants and animals and has vital roles in biological processes as production of energy, signal transduction, regulation of gene expression and synthesis of fatty acids, cholesterol and steroids, while the deficiency of nicotinic acid in man leads to complex pathological condition, known as pellagra. Tobacco is main source of nicotine and approximately 0.6% to 8.0% of nicotine is present in various part of tobacco plant. In present study extraction of nicotine from tobacco waste was carried out, further the extracted nicotine was subjected to oxidation for the synthesis of nicotinic acid by using hydrogen peroxide. Reaction parameters such as temperature, time, volume and concentration of toluene and hydrogen peroxide were optimized. In result, 1.2 g of nicotine was extracted from tobacco waste at 600C in 150ml toluene in 6 h. Whereas 3.87 g of nicotinic acid was procured by using 50 ml, 2M solution of hydrogen peroxide in 8 h time at temperature 70 0C. Extracted nicotine and nicotinic acid was characterized by mass spectroscopy and fourier transforms infrared spectroscopy respectively.

extraction, nicotine, nicotinic acid, niacin, vitamin, oxidation.

"Synthesis, Characterization and Optimization Study of Nicotine Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.584-589, August-2018, Available :http://www.jetir.org/papers/JETIR1808562.pdf

"Synthesis, Characterization and Optimization Study of Nicotine Derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp584-589, August-2018, Available at : http://www.jetir.org/papers/JETIR1808562.pdf