• Sumit Kumar
• Alka N.Choudhary
• Manish Mishra

Solubility is the most important physical characteristic of a drug for its oral bioavailability, formulation, development of different dosage form of different drugs and for quantitative analysis. The present review summarizes about solubility of the drug is the most important factor that controls the formulation of the drug as well as therapeutic efficacy of the drug, hence the most critical factor in the formulation development. The applicability and effectiveness of drug depends to a considerable extent on solubility in water. The hydrotropic solubilization techniques can be used to enhance the solubility of the drug. In present scenario this method is getting lot of values and may be proved the best method in future. Solubilisation process whereby addition of a large amount of second solute results in an increase in the aqueous solubility of another solute and the chemicals which are used in hydrotropy are called hydrotropes. Various drugs can be analyzed by combination of conventional analysis methods like spectrophotometer and chromatography with hydrotropes.

Solubility, Hydrotropy, Mechanism of hydrotropy, mixed hydrotropy

"A Review on Novel Solubility Enhancement Technique Hydrotrophy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.991-998, August-2018, Available :http://www.jetir.org/papers/JETIR1808627.pdf

"A Review on Novel Solubility Enhancement Technique Hydrotrophy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp991-998, August-2018, Available at : http://www.jetir.org/papers/JETIR1808627.pdf