• k.venkata gopaiah

Conventional treatment of inflammatory bowel disease is based on the daily administration of high doses of immune-suppressant or anti-inflammatory drugs, is very complicated by serious adverse effects. A carrier system that delivers the drug specifically to the inflamed intestinal regions and shows prolonged drug release would be desirable. It may enter any portion of the gastrointestinal tract though it is mostly found in the terminal ileum often with extension into the cecum and sometime into the ascending colon. Half of the cases, multiple areas of both small and large intestine are involved in segmental fashion i.e. lengths of normal intestine separate areas of disease called skip area. Crohn’s disease granulomatous colitis. Lesions of the small and large bowels are associated with anal lesions it is the first manifestation of the disease Inflammatory bowel disease is mostly common in western countries and in some areas of northern latitude. Polymeric nanoparticles can increase the permeability of an ulcerative colitis through biological barriers, such as the mucosal barriers, skin barriers and cell membrane barrier. The conventional treatments are mostly restricted to control inflammations. However, the main Aim of clinical ulcerative colitis therapy is to not only to control inflammation, but also to achieve mucosal healing. Therefore, the novel therapeutic strategies are urgently needed for addressing the limitations of existing treatments will Increase the stability of any of the volatile pharmaceutical agents, easily and also can be cheaply fabricated in large quantities by a multitude of methods. Delivers a higher concentration of pharmaceutical agent to a desired location.

Dissociation of the drug from the polymer and from it’s de-adsorption (or) release from the swelled nanoparticles

"LIPID POLYMER BASED NANO PARTICLES FOR THE THEROPY OF ULCERATIVE COLITIS TO IMPROVE THE THERAPEUTIC EFFICIENCY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.124-131, August-2018, Available :http://www.jetir.org/papers/JETIR1808658.pdf

"LIPID POLYMER BASED NANO PARTICLES FOR THE THEROPY OF ULCERATIVE COLITIS TO IMPROVE THE THERAPEUTIC EFFICIENCY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp124-131, August-2018, Available at : http://www.jetir.org/papers/JETIR1808658.pdf