• Mrinalini C. Damle
• Swapnil S. Waghmare
• Purushotam Sinha

A simple, economical and precise thin-layer chromatography method has been developed for determination of Paliperidone palmitate. The method was validated as per International Conference on Harmonization (ICH) guidelines. Aluminium TLC plates precoated with silica gel 60F254 were used as the stationary phase and chloroform: methanol 3:7 (v/v) as mobile phase. A compact band (Rf 0.54 ± 0.03) was obtained for Paliperidone palmitate. Densitometric analysis was performed in the absorbance mode at 236 nm. The calibration curve was found to be linear in the concentration range of 500-2500 ng/band. The limits of detection and quantitation were found to be 47.70ng/band and 144.56ng/band respectively. Paliperidone palmitatae was subjected to stress conditions like hydrolysis under acidic, basic and neutral conditions, oxidation, heat and photolysis.

: Paliperidone Palmitate, HPTLC, Stability indicating method

"Development and validation of stability indicating hptlc method for determination of Paliperidone palmitate as bulk drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.309-316, August-2018, Available :http://www.jetir.org/papers/JETIR1808688.pdf

"Development and validation of stability indicating hptlc method for determination of Paliperidone palmitate as bulk drug", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp309-316, August-2018, Available at : http://www.jetir.org/papers/JETIR1808688.pdf