• DR SHARADA A C
• PUNEETH H R

A series of curcumin pyrazole derivatives (2a & 2b) were synthesized and the structures were determined by 1H and 13C NMR spectroscopic techniques. The purity of the compounds was confirmed by LC-MS. The curcumin and its pyrazole series (2a & 2b) along with standard drugs were assessed for in vitro antioxidant and anticancer activities. From the present findings, the compound 2a possess promising in-vitro anticancer and antioxidant potency compared to that of natural curcumin. The synthetic analogue of curcumin, compound4,4'-(1E,1'E)-2,2'-(1-(4-chlorophenyl)-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol) (2a) could be a promising economical drug effective at non-toxic doses and necessitates in-vivo investigations.

Curcumin pyrazoles, antioxidant, trypan blue, anticancer

"A study on synthesis and biological evaluation of curcumin pyrazole derivatives for anticancer and antioxidant properties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.594-601, August-2018, Available :http://www.jetir.org/papers/JETIR1808728.pdf

"A study on synthesis and biological evaluation of curcumin pyrazole derivatives for anticancer and antioxidant properties", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp594-601, August-2018, Available at : http://www.jetir.org/papers/JETIR1808728.pdf