• Mr Smit Patel

In response to the global challenge posed by the COVID-19 pandemic, extensive research efforts are underway to identify potential antiviral agents. This study employed molecular docking analysis to investigate the binding properties of 3-mesityl-1-(thiophen-2-yl)prop-2-en-1-one, a chemical compound, against the main protease (6LU7) associated with the COVID-19 virus. The ligand and protein were prepared, and molecular docking was performed to assess the binding affinity of the compound. The results revealed multiple binding interactions, including hydrogen bonds and hydrophobic interactions, highlighting the strong affinity of 3-mesityl-1- (thiophen-2-yl)prop-2-en-1-one for the main protease. This research contributes to the ongoing efforts to discover potential antiviral agents for COVID-19.

CO-19, Main Protease, Mesityl, Thiophen,

"Assessing the Inhibitory Latent: Molecular Cropping of 3-mesityl-1-(thiophen-2-yl)prop-2-en-1- one beside SARS-CoV-2 Central Protease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 8, page no.188-191, August-2018, Available :http://www.jetir.org/papers/JETIR1808B25.pdf

"Assessing the Inhibitory Latent: Molecular Cropping of 3-mesityl-1-(thiophen-2-yl)prop-2-en-1- one beside SARS-CoV-2 Central Protease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 8, page no. pp188-191, August-2018, Available at : http://www.jetir.org/papers/JETIR1808B25.pdf