• shayan shakeel
• Ajay Kumar Sharma

Objectives: -The study was undertaken to establish data on the comparative status of cytokine concentration in healthy pregnancy, labour and non-pregnant subjects. We investigated and established the values of IL-1 beta, IL-6, IL-8, TNF-alpha and IL-10 during all phases of human pregnancy, labour as well as in the non-pregnant control state. Methods: - A cross-sectional assessment of serum IL-1 beta, IL-6, IL-8, TNF-alpha and IL-10 in healthy pregnant women at antenatal visits and labour with corresponding clinical history deciphered through questionnaire. Results: - Statistically peak value of IL-1 beta has been recorded in 3rd trimester and labour (p˂.0001) when compared to non-pregnant subject. The study demonstrated significant increase in IL-6 across 2nd trimester, 3rd trimester and labour as compared to non-pregnant subject. A statistically significant peak value of IL-8 was recorded in 3rd trimester and labour as compared to non-pregnant subject (p˂.0001).TNF –alpha presented a stable production profile at all phases of pregnancy and labour. Statistically elevated values of IL-10 was recorded in 3rd trimester and labour (p˂.0001). Conclusion:- As the pregnancy progresses, maternal shifts away from type-2 dominated immune response to an inflammatory response, thus supporting the concept that labour resembles an inflammatory response. Further research is the current demand to establish reference values differentiating physiology from pathology and refining oversimplified concept of immunesupression or Th2 – biased phenomenon of pregnancy. Utilizing this knowledge and further research may be boonful in setting up of therapeutic interventions in the future.

cytokine pregnancy

"cytokine profiling in clinical isolates of pregnant and non-pregnant subjects at Hazaribag district of Jharkhand", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 9, page no.643-649, September-2018, Available :http://www.jetir.org/papers/JETIR1809236.pdf

"cytokine profiling in clinical isolates of pregnant and non-pregnant subjects at Hazaribag district of Jharkhand", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 9, page no. pp643-649, September-2018, Available at : http://www.jetir.org/papers/JETIR1809236.pdf