• mansi butola
• sayantan mukhopadhyay

The main objective of the present investigation was to formulate and characterise microemulsion for ocular drug delivery.70% of the ophthalmic preparations are conventional dosage forms, extensive pre corneal loss caused by rapid drainage and high tear liquid are the main drawbacks associated with these systems, only 1 to 5% of the total drug penetrates into cornea and reaches to the intraocular tissue, to overcome these problems, microemulsion based systems are developed. In the first step solubility of drug in oil and surfactant was checked to identify components of microemulsion. The microemulsion was prepared by using oleic acid as an oil phase, tween 80 as surfactant, ethanol as co surfactant and 0.5 N NAOH as aqueous phase. The appropriate amount of drug was introduced into the oil phase with continues magnetic stirring, the mixture of surfactant and co surfactant was added into the oil phase with vigorous stirring, aqueous phase was added drop wise to form a transparent and stable microemulsion. The prepared microemulsion was evaluated for visual observation, PH, Particle Size and Zeta potential. The microemulsion prepared was appeared to be transparent, isotropic, monophasic and dynamic in nature, and have low viscosity with Newtonian behaviour, the PH value ranges from 6.8±7.1, particle size was found in micro range 213.2±100%, zeta potential -12.8.

KEYWORDS: microemulsion, ocular delivery, surfactants, isotropic

"MICROEMULSION IN OCULAR DRUG DELIVERY; A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 11, page no.256-270, November-2018, Available :http://www.jetir.org/papers/JETIR1811438.pdf

"MICROEMULSION IN OCULAR DRUG DELIVERY; A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 11, page no. pp256-270, November-2018, Available at : http://www.jetir.org/papers/JETIR1811438.pdf