• T.Thangaratham
• S.K. Sundar

The aim of the present Insilico studies is to find out the potential protein target in stationary phase-induced biofilm regulator (E. coli –dosP) and deliver the 3D structure and to introduce the best inhibitors of aldehydes (Sumatriptan) using molecular drug docking techniques. The potential chemical compound, Aldehyde (Sumatriptan) was retrieved from NCBI PUBCHEM compound database and converted into 3D structure using online smiles translator and finally docking studies were done on the modelled protein target (E. coli –dosP) using an automated molecular docking server PATCHDOCK. So, we suggest that Sumatriptan potentially inhibits and has the best anti-bacterial activity for the target protein, namely, E. coli – dosP. The aldehyde chemical compound, Sumatriptan is the best therapeutic agent in Bacteria (E. coli)

Sumatriptan, Potential protein, Docking technique

"PROTEIN MODELING AND DRUG DOCKING STUDIES ON POTENTIAL PROTEIN TARGET (E.coli – DOSP) AND COMPOUND ALDEHYDE (SUMATRIPTAN) USING IN SILICO METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 11, page no.264-270, November-2018, Available :http://www.jetir.org/papers/JETIR1811840.pdf

"PROTEIN MODELING AND DRUG DOCKING STUDIES ON POTENTIAL PROTEIN TARGET (E.coli – DOSP) AND COMPOUND ALDEHYDE (SUMATRIPTAN) USING IN SILICO METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 11, page no. pp264-270, November-2018, Available at : http://www.jetir.org/papers/JETIR1811840.pdf