• B. Jesvin Bency
• P. A. Mary Helen

The leaves of Tinospora cordifolia and Carica papaya has been used as home remedy based on indigenous cultural beliefs and experience to prevent and treat dengue fever. In silico search of potential inhibitors to dengue virus by molecular docking could identify the possible target binding pockets, generate aligned ligand poses and helps to prioritize the predicted active compounds. In this study, upon computational screening for drug-likeness or ADME parameters, a total of 28 compounds in T. cordifolia and 24 compounds in C. papaya passed Lipinski’s rule. These compounds were docked to 3 dengue targets Glyco-protein E, NS2B-NS3, NS1 based on which 7 ligands were shortlisted as potential ligands with high binding affinities. The results showed that Tinosponone in Tinospora cordifolia was found to be potent inhibitor of NS2B-NS3 receptor in Dengue virus because it exhibited maximum binding affinity (−2.8 kcal/ mol) and minimum docking score (−5.5 kcal/ mol) and free (−4.5 kcal/ mol) energy. The current study has virtually screened 2 potential anti-dengue inhibitors namely Tinosponone in Giloy and Crotonoyl bromide in Papaya which could be proposed as good drug candidates for the development of new drugs for dengue.

Dengue, Tinospora cordifolia, Carica papaya, molecular docking, Glyco-protein E, NS2B-NS3, NS1, Tinosponone.

"In silico identification of dengue inhibitors in Giloy (Tinospora cordifolia) and Papaya ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.506-511, December-2018, Available :http://www.jetir.org/papers/JETIR1812272.pdf

"In silico identification of dengue inhibitors in Giloy (Tinospora cordifolia) and Papaya ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp506-511, December-2018, Available at : http://www.jetir.org/papers/JETIR1812272.pdf