• Shaik Rahber
• Jaiprakash Sharanappa Biradar

Abstract: Simple and efficient one-pot method has been developed for the synthesis of indolyl-3,4-dihydroacridinone analogues (4a-4p) in good yields using 2,5-Disubstituted indole-3-carboxaldehyde, 5,5-dimethylcyclohexane-1,3-dione and 4-substitued anilines. The structures of all newly synthesized compounds have been characterized based on IR, 1H, 13C NMR, Mass spectral data and elemental analysis. All the compounds have shown very good in vitro antimicrobial and antioxidant activities. Further, in silico molecular docking study indicates that the synthesized compounds are novel inhibitors of the enzyme Glucosamine-6-phosphate synthase.

Indole-3-carboxaldehyde, Dihydroacridinone, Antimicrobial Activity, Antioxidant Activity, Molecular Docking.

"One-Pot Three Component Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Indolyl-3,4-dihydroacridinones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.116-135, December-2018, Available :http://www.jetir.org/papers/JETIR1812318.pdf

"One-Pot Three Component Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Indolyl-3,4-dihydroacridinones", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp116-135, December-2018, Available at : http://www.jetir.org/papers/JETIR1812318.pdf