• B. Aruljothi
• P. Sangeetha

The present study evalutes toxicity of cadmium and its impact on biochemical constituents like structural enzymes (AST and ALT) ,metabolic enzymes (LDH and SDH),antioxidant(GSH and GPx),total protein and lipid levels in some selected tissues in the freshwater fish labeo rohita and how selenium counters its toxic manifestations and metal antitode by some biochemical studies.the evaluation of AST and ALT activities are highly sensitive and useful criteria in predicting the early cell injury .Increased activities of AST and ALT in cadmium treated fish clearly signifies the increased gluconeogenesis. A significant depression of cellular metabolism enhancement of SDH and LDH activities were observed in the various tissues of cadmium treated fishes. Cadmium induced the early oxidative stress by producing free radicals and thus caused the lipid peroxidation and defects in the antioxidant status (GSH, GPx and TSH )of the fish .Significant decline in the tissue protein level in cadmium exposed labeo rohita clearly indicate the protein catabolism as a source of energy under metal stress. The metal chelator ,selenium had been proved to a better antitode against cadmium toxicity by neutralizing the toxic biochemical effects of cadmium. It can be concluded that the use of selenium have the capacity to alleviate many of the harmful effects of cadmium.

Key words: toxicity of cadmium, freshwater fish, gluconeogenesis, chelator and selenium

"Studies on the biochemical changes in the fresh water fish Labeo rohita (HAM) exposed to the cadmium combined with cadmium selenium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.509-516, December-2018, Available :http://www.jetir.org/papers/JETIR1812472.pdf

"Studies on the biochemical changes in the fresh water fish Labeo rohita (HAM) exposed to the cadmium combined with cadmium selenium.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp509-516, December-2018, Available at : http://www.jetir.org/papers/JETIR1812472.pdf