• V. Anu
• Dr. S. Ilayaraja
• Dr. A. John Merina

The isolation of Apigenin -7- O - (6- O - caffeoyl) - β - D - glucopyranoside was obtained from Coccinia grandis and the structure was established based on analysis of UV, 1H NMR and 13C NMR spectroscopy methods. Anti-ulcer activity of Apigenin -7- O - (6- O - caffeoyl) - β - D - glucopyranoside of Coccinia grandis was examined on pyloric ligated induced ulcer model in rats. The anti-ulcer activity of isolated compound from Coccinia grandis was estimated with the help of pH, gastric volume, free acidity, total acidity and ulcer index. The isolated compound showed substantial reduction in pH, gastric volume and ulcer index in dose dependent manner as compared to control and did not produce any toxic effects even at high doses.

Coccinia grandis, Apigenin -7- O - (6- O - caffeoyl) - β - D - glucopyranoside, pyloric ligation.

"ANTI-ULCER ACTIVITY OF APIGENIN -7- O - (6- O - CAFFEOYL) - β - D - GLUCOPYRANOSIDE ISOLATED FROM COCCINIA GRANDIS FLOWERS AGAINST PYLORIC LIGATION INDUCED ULCER IN ALBINO RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.53-56, December-2018, Available :http://www.jetir.org/papers/JETIR1812610.pdf

"ANTI-ULCER ACTIVITY OF APIGENIN -7- O - (6- O - CAFFEOYL) - β - D - GLUCOPYRANOSIDE ISOLATED FROM COCCINIA GRANDIS FLOWERS AGAINST PYLORIC LIGATION INDUCED ULCER IN ALBINO RATS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp53-56, December-2018, Available at : http://www.jetir.org/papers/JETIR1812610.pdf