• Dr. Vijaykumar. L. Chavan
• Mrs. Swati. S. Jaydeokar

The present work relates to a new process for separating the two optical isomers of optically active 2,2-dimethyl-3(2,2-disubstituted vinyl)-cyclopropanecarboxylic acid using N-benzyl -d-2-aminobutanol .Thus, the resolving agent for the present work can be prepared from readily available starting materials and also can easily be recovered from the reaction mixture after the resolution reaction in a high yield and further shows excellent resolving effect, and hence, it is a promising resolving agent. Further the resolution process is optimised by using suitable polar solvent to enhance enantiomeric excess. A method of present work, wherein (±)-cis or (±)-trans-cypermethric acid is reacted with a resolving agent; the resultant diastereomer salt is separated from the reaction mixture; the separated diastereomer is treated first with an acid and then with a base to obtain resolving agent. It is accordingly an object of this work to provide a process for optically resolving (±)-trans- cypermethric acid to obtain intended products of high purity in high yield at low costs.

Chirality, resolution of drug intermediates, preferential crystallisation, diastereomeric salt formation, enantiomeric excess.

"PROCESS FOR THE SEPARATION OF THE (DL) CIS-TRANS-2,2-DIMETHYL-3-(2,2-DISUBSTITUTEDVINYL)-CYCLOPROPANE-1-CARBOXYLIC ACID FROM ITS OPTICAL ISOMERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.255-261, December-2018, Available :http://www.jetir.org/papers/JETIR1812734.pdf

"PROCESS FOR THE SEPARATION OF THE (DL) CIS-TRANS-2,2-DIMETHYL-3-(2,2-DISUBSTITUTEDVINYL)-CYCLOPROPANE-1-CARBOXYLIC ACID FROM ITS OPTICAL ISOMERS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp255-261, December-2018, Available at : http://www.jetir.org/papers/JETIR1812734.pdf