• Dr. Sanganna V. Nishti
• Dr. S. M. Hanagodimath

Indole ring system is found in many natural products, pharmaceuticals agents, and polymer materials. Indole and its derivative have great importance in clinical chemistry. The Indole derivative chosen for the present study is pharmacologically active molecule. The solvent polarity effect on fluorescence quenching of 2-[2-(1H-indol-3-yl)-4-oxo-thiazolidin-3-ylamino]-5-oxo-5,6-dihydro-4H-[1,3,4]thiadiazine-6-carboxylic acid ethyl ester (IDCE) by carbon tetrachloride (CCl4) in benzene and acetonitrile mixtures has been studied at room temperature by steady state fluorescence measurements. The positive deviation from linearity in different composition of mixed solvents at different CCl4 concentration was observed from Stern-Volmer plots. The quenching parameters have been determined using extended S-V equation and found to be dependent on the polarity of the solvents. This indicates that both static and dynamic quenching processes are responsible for the observed fluorescence quenching. Further, it is concluded that the bimolecular quenching reactions are diffusion limited (finite sink approximation model), and the distance parameter and mutual diffusion co-efficient D are also estimated.

Indole, Fluorescence Quenching, Solvent Polarity and Binary Mixtures

"Binary Mixture Studies on the Fluorescence Quenching of Pharmacologically Potent Indole Derivative By CCl4", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.5, Issue 12, page no.1426-1431, December-2018, Available :http://www.jetir.org/papers/JETIR1812E05.pdf

"Binary Mixture Studies on the Fluorescence Quenching of Pharmacologically Potent Indole Derivative By CCl4", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.5, Issue 12, page no. pp1426-1431, December-2018, Available at : http://www.jetir.org/papers/JETIR1812E05.pdf