• RAJAMANICKAM KANNADHASAN
• DHANDAYUTHAM SARAVANAN
• SUBHASH CHANDER
• SNKARANARAYANAN MURUGESAN

Some of 2-oxo-6-[(1,3-benzothiazole-2-ylthio)-substituted phenyl-1, 2, 3, 4-tetrahydro pyrimidine-5-carboxylate ethyl ester derivatives were synthesized by reacting 1,3-benzothiazole-2-thiol substituted acetoacetate with urea and substituted aryl aldehydes in the presence of hydrochloric acid. All the titled compounds were characterized by FT-IR, MS, 1H and 13C-NMR spectral data. This set of synthesized compounds were evaluated for their antimicrobial potential against four bacterial strains (E.Coli, S.aureus, K.pneumonia and B.subtilis) and two fungal strains (C.albicans and A.niger) by disc diffusion technique. In an attempt to understand the exact ligand-protein interactions in terms of binding affinity, docking studies were also performed against glucosamine-6-phosphate synthase enzyme.

Benzothiazole, tetrahydropyrimidine, antimicrobial, docking

"Synthesis and study of novel 2-oxo-6-[(1, 3-benzothiazole-2-ylthio)- substituted phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate ethyl ester derivatives as antimicrobial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.740-751, January-2019, Available :http://www.jetir.org/papers/JETIR1901195.pdf

"Synthesis and study of novel 2-oxo-6-[(1, 3-benzothiazole-2-ylthio)- substituted phenyl-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate ethyl ester derivatives as antimicrobial agents", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp740-751, January-2019, Available at : http://www.jetir.org/papers/JETIR1901195.pdf