• Ms. Vijila Helen Mary
• Dr. G. Viswanathan,
• Dr. M. Michael Babu
• Dr. S. Antony

The antibiotic resistance is a problem of deep concern both in hospital and community setting. Production of extended spectrum beta lactamase is a significant resistance mechanism that impedes the antimicrobial treatment of infection caused by Enterobacteriacae. ESBL are rapidly evolving group of beta lactamase which share the ability to hydrolyze third generation cephalosporin but are inhibited by clavulanic acid. In this present work about 25 urine samples was collected from Medical College. About seven different strains were isolated and identified. Detection of ESBL producers were carried out by many methods with included screening for ESBL producers and phenotypic confirmatory test. It was observed that E.coli, Klebsiella pneumonia and Pseudomonas sp are the common ESBL producers. Identifying ESBL producing organism is a major challenge for the clinical microbiology. Further the isolated ESBL producing gram negative bacteria underwent antimicrobial susceptibility test using Kirby Bauer method. E.coli showed more sensitivity to nitrofuratoine, gentamicin. Pseudomonas sp showed sensitivity towards gentamicin, meropenem, ciprofloxacin. K. pneumoniae showed towards imipenem, gentamicin, piperacillin and meropenem. There is no doubt that ESBL producing infections are a grave concern to medical world. The aim of this study was to determine the rate of ESBL producing Gram-negative bacteria causing nosocomial Urinary Tract Infection as well as their susceptibility pattern to the most commonly used antimicrobials to identify the most appropriate antibiotic treatments for these infections.

Antibiotic resistance, Enterobacteriacae, Urinary Tract Infection, Gentamicin

"Extended Spectrum beta lactamase producing gram negative bacteria causing nosocomial Urinary tract infection and its susceptibility pattern", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.310-316, January-2019, Available :http://www.jetir.org/papers/JETIR1901340.pdf

"Extended Spectrum beta lactamase producing gram negative bacteria causing nosocomial Urinary tract infection and its susceptibility pattern", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp310-316, January-2019, Available at : http://www.jetir.org/papers/JETIR1901340.pdf