• Sakthivel jegan
• Gnanaprakasam Adaikala Raj
• Manivachagam Chandrasekaran
• Venugopalan Venkatesalua

The present investigation was carried out to evaluate the antiMRSA activity of Caulerpa chemnitzia (Epser) J.V. Lamououx, C. racemosa (Frosk.) Weber-van-Bosse, C. scalpelliformis (R.Br.) Weber-van-Bosse, Ulva lactuca Lin, U. fasciata Dellie, and U. reticulata Forsk, (Chlorophyceae) collected from the various places of Gulf of Mannar Coast, Tamilnadu, India. The hexane, chloroform, ethyl acetate, acetone and methanol extracts of selected marine green algae were screened against Staphylococcus aureus (MTCC 737 & 7443) and three clinical isolates of MRSA were tested. The extent of inhibitory zone, Minimum inhibitory concentrations (MIC) and Minimum Bactericidal Concentrations (MBC) were determined. The ethyl acetate extract showed the presence of phytochemicals, terpenoids, tannins and phenolic compounds strongly than the other solvent extracts. The highest antibacterial activity was recorded in the ethyl acetate extract of C. racemosa than the other extracts. The mean zone of inhibition produced by the extracts in agar disc diffusion assays against the tested bacterial strains ranged from 7.1 to 19.3 mm. The lowest MIC (125 µg/ml) and MBC (250 µg/ml) values were observed in the ethyl acetate extract of C. racemosa inhibition of S. aureus (737 & 7443), MRSA1 and MRSA3. These finding suggests that the ethyl acetate extract of C. racemosa can be used as an antibacterial substance for the treatment of Methicillin Resisitant S. aureus causing acquired infection. Further, the isolation of antibacterial compound from the ethyl acetate extract of C. racemosa is in progress.

Marine Macro Green Algae; MRSA and MSSA; Disc diffusion; MIC and MBC.

"Anti-MRSA activity of Caulerpa and Ulva species from Gulf of Mannar Coast, South India", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.78-99, January-2019, Available :http://www.jetir.org/papers/JETIR1901611.pdf

"Anti-MRSA activity of Caulerpa and Ulva species from Gulf of Mannar Coast, South India", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp78-99, January-2019, Available at : http://www.jetir.org/papers/JETIR1901611.pdf