• V.K.Kannan
• D.V. Patil
• Samadhan R. Patil
• Raju M Patil
• R.S.Lokhande

: A novel series of Chalcone derivatives were prepared by Claisen-Schmidt condensation of substituted 2’-Hydroxy-4,5-dimethyl acetophenone and substituted aromatic aldehydes like 2-Flurobenzaldehyde, 3-Flurobenzaldehyde, 3-Nitrobenzaldehyde, 3- Hydroxy benzaldehyde, 2-trifluromethyl benzaldehyde, 1-Naphthaldehyde, 5-bromo salicylaldehyde, 2,5-dimethoxy benzaldehyde, 1,4-terphthaldehyde and Indole-3- carboxyaldehyde in alkaline media at ambient temperature. The structure of synthesized Chalcones derivatives were elucidated by various spectroscopic techniques like IR, 1H-NMR, 13C NMR, UV, and Mass spectral analysis. Purity of the substances was determined by high performance liquid chromatography (HPLC). The Chalcones were also used for the estimation of biological properties like antibacterial, antifungal and antioxidant activities.

Chalcones, 2-hydroxy-4 5-dimethyl acetophenone, substituted aldehydes, Antibacterial activity, Antioxidant

"SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY OF NEW CHALCONES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.462-473, January-2019, Available :http://www.jetir.org/papers/JETIR1901863.pdf

"SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY STUDY OF NEW CHALCONES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp462-473, January-2019, Available at : http://www.jetir.org/papers/JETIR1901863.pdf