• Shailendra Kumar
• Sinu Bharti

This work was conducted to investigate the effect of sodium arsenite on superoxide dismutage (SOD) in arsenic induced mice and arsenic exposed ovarian cancer patients of Gangetic zone of Bihar. Female Swiss albino mice (n= 35) were selected as experimental animals. Arsenic treated mice were grouped into 5 groups. Normal women (n= 25) and arsenic exposed ovarian cancer patients (n= 50) from arsenic affected districts of Bihar were selected as the human model and blood samples were collected with their prior consent of the subjects. It was observed that the activities of SOD of ovarian tissue of all arsenic treated groups were significantly (p < 0.01) lower than that of the control group. The SOD activity decreased significantly (p < 0.05 for Bhagalpur and p < 0.01 for rest of the districts) in ovarian cancer patients form all the arsenic hit districts as compared to the normal women from those districts. The present data suggests that SOD activity was significantly reduced in the ovarian tissues of both mice and human model.

Sodium arsenite, Swiss albino mice, Ovary, Superoxide dismutage, Ovarian cancer

"Comparative Study of SOD Activities in the Ovarian Tissue of Arsenic Induced Female Mice and its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.1556-1560, January-2019, Available :http://www.jetir.org/papers/JETIR1901D14.pdf

"Comparative Study of SOD Activities in the Ovarian Tissue of Arsenic Induced Female Mice and its Correlation with Ovarian Cancer Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp1556-1560, January-2019, Available at : http://www.jetir.org/papers/JETIR1901D14.pdf