• Y. Sravanthi Reddy
• L. Matsyagiri

The objective of this study was to develop effective bioadhesive buccal bilayered tablets comprising of drug containing bioadhesive layer and drug free backing layer, expected to release the drug in unidirectional for extended period of time. Tablets of Granisetron were prepared by direct compression method using bioadhesive polymers like Carbopol 934P, HPMC K4M in different combinations and concentrations with backing layer of ethyl cellulose. Buccal tablets were evaluated by different parameters such as thickness, hardness, weight uniformity, content uniformity, swelling index, surface pH, ex vivo bioadhesive strength, ex vivo residence time, in vitro drug release, ex vivo drug permeation, stability studies in human saliva, in vivo mucoadhesive performance studies and FTIR studies. The drug release rate of formulations prepared with HPMC K4M (63.7±0.7was retarded due to the high viscosity of the polymer and formation of complex matrix network when compared to the other polymers. The optimized formula (F4) followed non-fickian release mechanism with zero order kinetics. The present study concludes that buccal delivery of Granisetron tablets can be good way to bypass the first pass metabolism.

Bioadhesive buccal bilayered tablets, direct compression, Granisetron.

"STUDY THE EFFECT OF POLYMERS AND DILUENTS ON BUCCAL TABLETS OF GRANISETRON ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.131-136, January-2019, Available :http://www.jetir.org/papers/JETIR1901H84.pdf

"STUDY THE EFFECT OF POLYMERS AND DILUENTS ON BUCCAL TABLETS OF GRANISETRON ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp131-136, January-2019, Available at : http://www.jetir.org/papers/JETIR1901H84.pdf