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January-2019
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Journal of Emerging Technologies and Innovative Research ( An International Scholarly Open Access Journal, Peer-reviewed, Refereed, Crossref DOI Journal )
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UGC Approved Journal no 63975(19)
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ISSN: 2349-5162 | ESTD Year : 2014 Volume 13 | Issue 3 | March 2026
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UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975
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JETIR1901I06
Registration ID:
524323
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Title
Synthesis of New Cu Complex Based on Natural 5Z,9Z Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin
Authors
Abstract
The complex (bipy)2Cu(5,9-eicd) was prepared by the reaction of Cu(OAc)2 with 5Z,9Z-eicosadienoic acid and 2,2′-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and efficiently inhibited human topoisomerase I. Using flow cytofluorometry, (bipy)2Cu(5,9-eicd) was studied for the effect on the cell cycle and apoptosis-inducing activity in tumor cells.
Key Words
Synthesis of New Cu Complex Based on Natural 5Z,9Z Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin
Cite This Article
"Synthesis of New Cu Complex Based on Natural 5Z,9Z Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.39-45, January-2019, Available :http://www.jetir.org/papers/JETIR1901I06.pdf
ISSN
2349-5162 | Impact Factor 7.95 Calculate by Google Scholar
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Cite This Article
"Synthesis of New Cu Complex Based on Natural 5Z,9Z Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp39-45, January-2019, Available at : http://www.jetir.org/papers/JETIR1901I06.pdf
Publication Details
Published Paper ID: JETIR1901I06
Registration ID: 524323
Published In: Volume 6 | Issue 1 | Year January-2019
Page No: 39-45
Country: -, -, India .
Area: Engineering
ISSN Number: 2349-5162
Publisher: IJ Publication
Published Paper URL :: https://www.jetir.org/view?paper=JETIR1901I06
Published Paper PDF: https://www.jetir.org/papers/JETIR1901I06
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