• Shiji Thomas

The rapid evolution of bacterial drug resistance and the alarming slowdown in development of new antibiotics is spurring attention towards multidrug treatments. Multiple drug resistance that continually challenges human health have resulted from the indiscriminate use of commercial antimicrobial drugs commonly used in the treatment of infectious diseases. A vicious cycle is generated as multidrug resistant pathogens force us to depend on additional broad-spectrum antibiotics to treat these infections, leading to yet more resistance. Whole-genome sequencing studies have been able to elucidate that bacteria evolve so rapidly with dozens of de novo drug-resistance mutations occurring at high frequency within a short period. This has initiated interest in research on novel and combination antibacterial therapies. Different antibiotics behave differently in combination when acting against various bacterial strains. This review summarizes the current knowledge of interactions between bioactive compounds from plants with commercially available antibiotics

Antibiotics, Bioactive compounds, Synergism, Additive effect, antagonistic effect

"INTERACTIONS OF BIOACTIVE COMPOUNDS FROM PLANTS AND ANTIBIOTICS: FOCUS ON ANTIBACTERIAL COMBINATION EFFECTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 1, page no.294-298, January-2019, Available :http://www.jetir.org/papers/JETIR1901J43.pdf

"INTERACTIONS OF BIOACTIVE COMPOUNDS FROM PLANTS AND ANTIBIOTICS: FOCUS ON ANTIBACTERIAL COMBINATION EFFECTS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 1, page no. pp294-298, January-2019, Available at : http://www.jetir.org/papers/JETIR1901J43.pdf