• Dr. Ajaykumar Soma Kolhe
• Dr. S. B. Chaudhari
• Dr. R. J. Verma

ABSTRACT : Aflatoxins are a secondary toxic fungal metabolites which commonly grow on human food and animal feeds. To study effects of aflatoxin, adult in bread rabbits were fed a diet containing 7.5 mg aflatoxin / kg feed for 90 days. A time dependent response was observed suggesting cumulative toxicity during aflatoxicosis.For haematological studies, blood samples from ear-pinna of rabbits were collected on 0, 7, 15, 30, 45, 60, 75 and 90 days of treatment and used. Results revealed that feeding aflatoxin contaminated diet caused a significant reduction In erythrocytes count and haemoglobin content. The decreases in RBC count and haemoglobin were continuous and time dependant. But the % reticulocyte count registered a time dependent increase during aflatoxicosis. Significant increase was recorded on 15th day of treatment and thereafter. Morphological alterations included Change in size of the erythrocytes. The number of small sized cells while the number of medium cells increased aflatoxicosis. Decreased.During No definite trend was evident in big cells. Initial Increase in number of big cells (7 and 15 days) was followed with a decrease. Much decrease in counts was noted on 30th and 45th day of treatment. Also average sized cells showed Increase except at 45th day of treatment where a decrease was recorded. Blood samples were also examined for total and differential counts of leucocytes. An Initial upsurge in total count was followed with time dependent significant decrease. The highest share of neutrophils and lymphocytes were accounted during differential counts of leucocytes. An initial upsurge followed by time dependent continuous decrease in number of neutrophils, eosinophils, basophils and monocytes were also noted during aflatoxicosis. But only neutrophils Lymphocytes count showed statisticallysignificant count registered an initial decline with time dependent increase.

Aflatoxin, Aflatoxicosis, Erythrocytes, Rabbits.

"STUDIES ON HEMATOLOGICAL ALTERATION OF RABBITS DURING AFLATOXICOSIS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.308-315, February-2019, Available :http://www.jetir.org/papers/JETIR1902148.pdf

"STUDIES ON HEMATOLOGICAL ALTERATION OF RABBITS DURING AFLATOXICOSIS.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp308-315, February-2019, Available at : http://www.jetir.org/papers/JETIR1902148.pdf