• Akanksha Goja
• GANESH BHATT

Topical therapy is desirable in the treatment of nail disease like onchomycosis which is a nail fungus causing thickened, ragged, brittle nail. The aim of the current work is to formulate the nail lacquer for the treatment of disease. The main purpose of the research was to provide a medicament over the nail for the extended period of time. Topical delivery of medicament over nail is limited due to poor permeability of drug into nail plate. There are some permeation enhancers which helps in enhancing the permeation. Eg thioglycolic acid and urea hydrogen peroxide. It works by reducing the disulfide bonds in the nail plate. Polymers like Carbopol, HPMC, Ethyl cellulose are used and plasticizer like propylene glycol is also used. Various evaluation parameter are performed for the nail lacquer like PH, drying time, viscosity, smoothness of flow, gloss respectively.The drug release %age was determined by UV spectrophotometer. FTIR study is performed which determines the drug and all excipients are compatible.

- Nail lacquer, Thioglycolic acid, permeation enhancer

"NAIL LACQUER AS A TRANSUNGUAL DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.177-186, February-2019, Available :http://www.jetir.org/papers/JETIR1902625.pdf

"NAIL LACQUER AS A TRANSUNGUAL DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp177-186, February-2019, Available at : http://www.jetir.org/papers/JETIR1902625.pdf