• CHINKEY MITTAL
• G.GANARAJAN

Chronomodulated drug delivery are lot of interest as they deliver the drug at the right site of action, at the right time and in the right amount which provides more benefits and to increasing patient compliance. It is time and site specific drug delivery system and thus provides spatial and temporal delivery. In these system in which the release of drug in the body is allowed to match with circadian rhythm of the disease, such as asthma, peptic ulcer, cardiovascular disease,arthritis,hypercholesterolemia.This system is programmed drug delivery system in harmonization with body clock. The pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Pulsatile release is also useful for the targeting of drug irritating the stomach or degradable, as well for drugs developing biological tolerance or with an extensive first pass metabolism. Current review article discussed the reasons for the development of chronomodulated drug delivery system, advantage, limitations, type of disease in which the pulsatile release is required, methodologies, and recent advances in chronomodulated drug delivery system.

Chronomodulated, lag time, disease, pulsatile release

"CHRONOMODULATED DRUG DELIVERY SYSTEM; A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.355-371, February-2019, Available :http://www.jetir.org/papers/JETIR1902645.pdf

"CHRONOMODULATED DRUG DELIVERY SYSTEM; A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp355-371, February-2019, Available at : http://www.jetir.org/papers/JETIR1902645.pdf