• Santhosha S.Poojary
• Dr. Devaraju
• Dr. Y. B. Basavaraju
• Dr. Umesha B
• Ranjini P

New substituted biphenyl derivatives of Valacyclovir 6a-e i.e. substituted 2-((2-(([1,1'-biphenyl]-4-ylmethyl)amino)-6-oxo-1H-purin-9(6H)-yl)methoxy)ethyl 2-amino-3-methylbutanoate were synthesized by general deprotection method using Pd/C in acetic acid under hydrogrn pressure. Substituted N-protected Biphenyl derivatives were synthesized by Steglich esterification with some changes in the experimental procedure. Compound 4 was prepared by N-protection of L-Valine. Substituted 2-(([1,1'-biphenyl]-4-ylmethyl)amino)-9-((2-hydroxyethoxy)methyl)-1H-purin-6(9H)-one i.e 3a-e were synthesized by general N-alkylation of Acyclovir with 2-substituted 4-(bromomethyl)-1,1'-biphenyl using K2CO3 and DMF. The synthesized compounds were confirmed by 1H NMR, 13C NMR, mass and IR spectrum. The synthesized compounds were screened for their antimicrobial and anti oxidant activities by comparing with Valacyclovir and control, compounds 6a-e showed considerable activity. Among the synthesized compounds, 6b exhibited more inhibition compared with remaining synthesized compounds.

Valacyclovir, biphenyl, Steglich, Acyclovir.

"Synthesis and Study of Biological Activities of Novel N2 Substituted Biphenyl Derivatives of Valacyclovir", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.251-256, February-2019, Available :http://www.jetir.org/papers/JETIR1902737.pdf

"Synthesis and Study of Biological Activities of Novel N2 Substituted Biphenyl Derivatives of Valacyclovir", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp251-256, February-2019, Available at : http://www.jetir.org/papers/JETIR1902737.pdf