• Dr. Anish Nag
• Rajshree Roy Chowdhury
• Neha Shrivastav

Haemophilus influenza is a pathogenic bacterium responsible for causing various diseases, especially to the children. Due to the numerous reports of antibiotic resistance against this bacterium, the necessity of employing alternative therapy is emphasized by various researchers. Herbal medicines are consistently proven to be successful for managing various pathogen related conditions by numerous researchers and in this backdrop our study aimed to study the role of phytocompounds against H. influenza, using DNA ligase as a drug target. Phytocompounds namely α humulene, zeumbone and camphene, isolated from the Zingiberaceous plant Z. zerumbet were subjected to study their inhibitory potentials against the bacterial enzyme DNA ligase, using a rigid body in silico docking method (PatchDock). The result indicated that these phytochemicals especially α humulene, may be successfully employed as an anti-bacterial agent against H. influenza.

Haemophilus influenza, Phytocopounds, Docking, DNA ligase

"Phytocompounds from Zingiber zerumbet can inhibit the DNA ligase activity of the pathogen Haemophilus influenza, an in silico approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.646-651, February-2019, Available :http://www.jetir.org/papers/JETIR1902788.pdf

"Phytocompounds from Zingiber zerumbet can inhibit the DNA ligase activity of the pathogen Haemophilus influenza, an in silico approach", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp646-651, February-2019, Available at : http://www.jetir.org/papers/JETIR1902788.pdf