• SATHOSH KUMAR*
• DIVYA BHARATHI JEKKULA
• BHAVANA PAMULAPATI
• AKHILA JANGA
• Dr. DEVENDER KODATI*

Aim: A concurrent and retrospective observational study to evaluate the effect of OCT2 substrates or inhibitors on cisplatin induced nephrotoxicity. Materials and Methods: A subject population of 364 was enrolled and categorized based upon the cisplatin dose and usage of OCT2 substrates/inhibitor. GFR was calculated by using Cockroft-Gault (CG) equation, during and after completion of cisplatin therapy. Two tailed T-test was used to observe the difference between GFR during and after chemotherapy. Results: According to the results, during cisplatin therapy, among 50mg/m2, 50-100mg/m2 most of the patients were grade IIIA, and in patients with >100mg/m2and OCT2 substrates/inhibitors usage, grade II is higher in proportion. After completion of cisplatin therapy, among subjects with cisplatin dose 50 mg/m2 and 50-100mg/m2 dose, grade IIIB is higher in proportion. In subjects with cisplatin dose above 100 mg/m2 and concurrent usage of OCT 2 substrates / inhibitors grade IIIA is higher in proportion. CONCLUSION: With single or two doses of cisplatin causes temporary decrease in GFR, whereas cumulative exposure may lead to glomerular damage. In patients with OCT2 substrates/inhibitors usage during therapy, cisplatin induced nephrotoxicity decreased due to competitive inhibition at OCT2 receptor site, whereas it is contrast with results obtained after cisplatin therapy i.e., nephrotoxicity is not affected by OCT2 substrates/inhibitors, because cumulative dose of cisplatin after completion of all cycles. It is concluded that effect of OCT2 can be observed temporarily i.e., only during therapy. This study mainly helps the medical professionals in assessing the effect of OCT2 substrates on cisplatin induced nephrotoxicity. Key-words: Nephrotoxicity, Organic cation transporter, Palliative, Tubular reabsorption, Anemia

: Nephrotoxicity, Organic cation transporter, Palliative, Tubular reabsorption, Anemia

"A STUDY ON EFFECT OF OCT2 SUBSTRATES / INHIBITORS ON CISPLATIN INDUCED NEPHROTOXICITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.254-260, February-2019, Available :http://www.jetir.org/papers/JETIR1902837.pdf

"A STUDY ON EFFECT OF OCT2 SUBSTRATES / INHIBITORS ON CISPLATIN INDUCED NEPHROTOXICITY ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp254-260, February-2019, Available at : http://www.jetir.org/papers/JETIR1902837.pdf