• Neha
• Dr Alok pal Jain
• Dr Shailesh Gupta

The purpose of the work was to formulate and evaluate the Indomethacin e transdermal patches with natural permeation enhancer for the controlled delivery of the drug in the body. Patches were formulated using various ratios of polymer HPMCK15M, (PVPK30) Polyvinyl Pyrrolidone and Ethyl Cellulose. Transdermal patches were formulated by solvent evaporation method. Transdermal patches were evaluated for various parameters like thickness, folding endurance, percentage moisture loss, percentage moisture absorption, drug content uniformity, stability studies, in vitro skin permeation and skin irritation test. All formulations possess excellent physicochemical properties and exhibited negligible skin irritation with good physical stability. Permeation study was performed by using modified Franz diffusion cells. On the basis of drug release and physicochemical values, formulation F5 with natural permeation enhancer was shows higher percentage of drug release at 24 hours. Release kinetics studies revealed that the drug release from formulations followed Higuchi kinetics.

The purpose of the work was to formulate and evaluate the Indomethacin e transdermal patches with natural permeation enhancer for the controlled delivery of the drug in the body. Patches were formulated using various ratios of polymer HPMCK15M, (PVPK30) Polyvinyl Pyrrolidone and Ethyl Cellulose. Transdermal patches were formulated by solvent evaporation method. Transdermal patches were evaluated for various parameters like thickness, folding endurance, percentage moisture loss, percentage moisture absorption, drug content uniformity, stability studies, in vitro skin permeation and skin irritation test. All formulations possess excellent physicochemical properties and exhibited negligible skin irritation with good physical stability. Permeation study was performed by using modified Franz diffusion cells. On the basis of drug release and physicochemical values, formulation F5 with natural permeation enhancer was shows higher percentage of drug release at 24 hours. Release kinetics studies revealed that the drug release from formulations followed Higuchi kinetics.

"FORMULATION AND EVALUATION OF INDOMETHACIN TRANSDERMAL PATCH CONTAINING NATURAL PENETRATION ENHANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 2, page no.1322-1334, February-2019, Available :http://www.jetir.org/papers/JETIR1902D88.pdf

"FORMULATION AND EVALUATION OF INDOMETHACIN TRANSDERMAL PATCH CONTAINING NATURAL PENETRATION ENHANCER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 2, page no. pp1322-1334, February-2019, Available at : http://www.jetir.org/papers/JETIR1902D88.pdf