UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 6 Issue 3
March-2019
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR1903524


Registration ID:
199753

Page Number

191-205

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Title

in-silico analysis of essential amino acids of Alpha-lactalbumin in different species and its association with regulatory proteins for the normal cellular metabolism for growing newborn.

Abstract

Alpha-lactalbumin consists of all the essential and nonessential amino acids, which play a dramatic role in developing newborn baby and be strong enough to fight any kind of the diseases by enhancing the immunity from neonatal baby to 6 years old child. It is a one of the crucial protein in the milk that participates in lactose synthesis and facilitates in milk production. However, the conscientious role of alpha-lactalbumin in interaction with different regulatory proteins and comparative nutritional value in different species are not much known. Here we showed that the percentage of essential amino acids composition in different species along with their interaction with regulatory proteins B4GALT, GLB1, GALE, LCT, GALT, FUT, NOTCH. We found the percentage of essential amino acids composition of alpha-lactalbumin by in-silico (prot-param) study in Human-50%, Bovine49.2%, pig-50.3%, Sheep-49.2%, Dog-48.6%, Horse-46.5, Rat-42.7%, Rabbit-50.3%, Yellow baboon-43.8% and edge confidence of regulatory protein interaction with alpha-lactalbumin are B4GALT1-0.996, GLB10.916, LCT-0.903, GALE-0.903, GALT-0.900 by String (a tool to predict the protein-protein interactions). Our result demonstrates the percentage composition of essential amino acids is higher in Pig and Rabbit in compare to other species in nutritional perspective while the edge confidence strongly inferred that alpha-lactalbumin regulate the process of cellular biosynthesis process, protein glycosylation and UDP catalytic activity etc. Furthermore the result of string also indicates that regulation of fut chaperone by alpha-lactalbumin, which is known for the post-translational modification (fucosylation) of Notch receptor protein.

Key Words

Alpha-lactalbumin, B4GALT, GLB1, GALE, LCT, GALT.

Cite This Article

"in-silico analysis of essential amino acids of Alpha-lactalbumin in different species and its association with regulatory proteins for the normal cellular metabolism for growing newborn.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.191-205, March-2019, Available :http://www.jetir.org/papers/JETIR1903524.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"in-silico analysis of essential amino acids of Alpha-lactalbumin in different species and its association with regulatory proteins for the normal cellular metabolism for growing newborn.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp191-205, March-2019, Available at : http://www.jetir.org/papers/JETIR1903524.pdf

Publication Details

Published Paper ID: JETIR1903524
Registration ID: 199753
Published In: Volume 6 | Issue 3 | Year March-2019
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.20147
Page No: 191-205
Country: Lucknow, Uttar Pradesh, India .
Area: Science
ISSN Number: 2349-5162
Publisher: IJ Publication


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