• K.ANUSHA
• Dr.K.V.RATNAMALA

Buccal route offers excellent opportunities and potential advantages for systemic drug delivery as compared to pre-oral administration. The objective of this study was to prepare Ropinirole hydrochloride buccal tablets. The Ropinirole Hydrochloride is a non-ergoline dopamine agonist with high relative specificity and full intrinsic activity at the D2 and D3 dopamine receptor subtypes. This action in humans correlates with treatment for Parkinson’s disease due to stimulation of postsynaptic dopamine D2-type receptors. Ropinirole hydrochloride after oral administration shows a lesser bio availability up to 55% with a biological half-life of 4 to 6hours. To increase the bioavailability has drug as good buccal absorption. Ropinirole hydrochloride buccal tablets were prepared by direct compression method using guar gum and badam gum as natural polymers, carbopol 934P and HPMC K15M as mucoadhesive polymers. Tablets were evaluated for physical properties, drug content, swelling index, mucoadhesion, and in-vitro dissolution studies. An optimized formulation F6 was found to be having good mucoadhesive strength 345.74mg, 352.84mg. ; mucoadhesive residence time was found to be more than 6 hours and cumulative percentage drug release 98.29%, 99.87% within 6hours.Release kinetic model studies indicated that optimized batch followed diffusive mechanism with zero order release kinetics.

Ropinirole hydrochloride, mucoadhesion, direct compression method, buffer, drug release studies

"FORMULATION AND EVALUATION OF ROPINIROLE HYDROCHLORIDE BUCCAL TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.520-536, March-2019, Available :http://www.jetir.org/papers/JETIR1903769.pdf

"FORMULATION AND EVALUATION OF ROPINIROLE HYDROCHLORIDE BUCCAL TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp520-536, March-2019, Available at : http://www.jetir.org/papers/JETIR1903769.pdf