• KAVYA V. REDDY
• ASHISH YACHAWAD
• Sangram Salunke
• Nagesh Tour
• Chavan G.C.

Nonionic surfactant vesicular systems, otherwise known as niosomes, are a novel and efficient approach to drug delivery. Their vesicular membrane is mainly composed of nonionic surfactants, cholesterol and charge inducer. I have selected Lidocaine HCl as drug candidate after extensive literature survey because Lidocaine HCl provide efficient anesthesia of the skin or of mucosal tissues in case of pain itching and burning associated with cutaneous inflammatory response to different agents and with minor surgical operations. But permeability of Lidocaine HCl through skin i.e. stratum corneum is very low, hence attempt made to improve the permeation of Lidocaine HCl across skin by synergistic effect of niosomes & iontophoresis. Niosomes also protects drug degradation which occurs due to electric current during iontophoresis. No niosomal system with iontophoresis for Lidocaine HCl has been formulated for local dermal anesthesia. In this work, niosomes are prepared by Rotary evaporation method & ether injection method, best method will be selected depending on entrapment efficiency & vesicle size. Different surfactants (Tweens and Spans) screened to select best surfactant depending on entrapment efficiency and vesicle size, span 60 optimized as best surfactant. 32 full factorial design was used to optimize the formula, the optimized batch was evaluated for Optical microscopy, vesicle size analysis and PDI, entrapment efficiency, in vitro release study, SEM analysis, zeta potential analysis and DSC study & best batch (F5) formulated in to gel. Permeation experiments for niosomal dispersion, simple marketed gel (Lignocaine HCl gel 2% I.P. i.e. LOX 2% Gel) & niosomal gel with or without iontophoresis using cellophane membrane was carried out and it shows that, niosomes and iontophoresis have synergistic effect on permeation flux. While performing iontophoresis of marketed gel it was observed that there is reduction in permeation of drug after 3 hr, it might be due to drug degradation due to electric current. To confirm this degradation, study was carried out on marketed gel and niosomal gel and results shows that niosomes offers protection of drug from electric current during iontophoresis.

Niosomes, Transdermal iontophoresis, Permeation flux

"Preparation and characterization of niosomal gel of lidocaine HCL for transdermal iontophoresis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.307-343, March-2019, Available :http://www.jetir.org/papers/JETIR1903F48.pdf

"Preparation and characterization of niosomal gel of lidocaine HCL for transdermal iontophoresis", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp307-343, March-2019, Available at : http://www.jetir.org/papers/JETIR1903F48.pdf