• Palki Hazarika
• Dr. Kamal Choudhury

ABSTRACT: The present study was done to observe the effects of Levonorgestrel (LNG), a progestin, on the uterine histoarchitecture of female rat. Adult cyclic female albino rats were divided into three groups: control, LNG treated (1.5mg/kg body weight/day) and sesame oil treated. Treatment was done sub-cutaneously for 06 consecutive cycles (one injection/cycle). Half of the animals were sacrificed after 24 hours of end of the treatment and half were left untreated for another two estrous cycles to observe sustainable effects, if any. Uterine histology together with their wet weight was studied in all the groups. Decreased wet weight of the uterus, narrow and elongated uterine lumen, decreased numbers of endometrial glands, thin luminal epithelial linning, decidualization of the stroma were observed both immediately after the treatment and even after two cycles of discontinuation of the treatment. The present study revealed that repeated or long term use of LNG doses may cause some permanent changes leading to malfunctioning of the female reproductive system which may be the cause of female infertility.

Key words: Progestin, endometrial glands, anti-estogenicity, infertility.

"Effects of Repeated Dose of Levonorgestrel on Uterine Histomorphology of Adult Female Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.581-587, March-2019, Available :http://www.jetir.org/papers/JETIR1903F79.pdf

"Effects of Repeated Dose of Levonorgestrel on Uterine Histomorphology of Adult Female Albino Rats", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp581-587, March-2019, Available at : http://www.jetir.org/papers/JETIR1903F79.pdf