• Lakshmi Prasanna Jakka
• Sudhakar Babu AMS
• Shainy M
• Mounika S
• Harshitha J

Current study was undertaken to investigate the release of the drug and analgesic activity of orally administered Diclofenac sodium chocolate dosage form by using tail flick and hot plate method in rat model. In these methods, heat is the source for pain. The time course for analgesia revealed maximum activity after 3 hours in both tail flick and hot plate methods. A constant heat (55°C) will be given to the animal by both hot plate and tail flick methods and the response of animals e.g. jumping, paw licking and withdrawal will be observed. The Diclofenac Sodium used for the analgesic activity (10mg/kg) was formulated as chocolate formulation and given orally. Both the test and standard drugs reduced the pain significantly as compare to the control group. The results of pharmacological tests performed in the present studies suggest that the drug is being release from the formulated dosage form and possess potent analgesic activity.

Analgesic activity, chocolate dosage form, diclofenac sodium, hot plate method.

"Evaluation of Analgesic Activity of NSAID In Chocolate Dosage Form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.388-391, March-2019, Available :http://www.jetir.org/papers/JETIR1903G55.pdf

"Evaluation of Analgesic Activity of NSAID In Chocolate Dosage Form", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp388-391, March-2019, Available at : http://www.jetir.org/papers/JETIR1903G55.pdf