• SHYMA M
• K R Haridas
• Sujith KV

Non-steroidal anti-inflammatory drugs (NSAIDs) are used in the treatment of pain, inflammation, osteoarthritis and rheumatoid arthritis.2-[4-(2-methyl propyl)phenyl]propanoic acid belonging to NSAIDs. Prolonged use of NSAIDs tends to cause gastrointestinal complications. The use of prodrugs to temporarily mask the acidic group of NSAIDs has been postulated as an approach to decrease gastrointestinal toxicity of these drugs. The 1, 2, 4-triazole is used for designing potential bioactive agents. Derivatives of this structure was prepared by reacting 2-[4-(2-methyl propyl)phenyl]propanoic acid and thiocarbohydrazide. The synthesized triazole and the parent compound were then subjected to cytotoxic studies on HepG2 cell line and comparative studies were done.

1,2,4-Triazole, Ibuprofen, NSAIDs, Prodrug, One-pot method

"COMPARITIVE CYTOTOXIC STUDIES OF 2-[4-(2-METHYL PROPYL) PHENYL]PROPANOIC ACID AND ITS 1,2,4-TRIZOLE DERIVATIVE ON HEPG2 CELL LINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.524-528, March-2019, Available :http://www.jetir.org/papers/JETIR1903G77.pdf

"COMPARITIVE CYTOTOXIC STUDIES OF 2-[4-(2-METHYL PROPYL) PHENYL]PROPANOIC ACID AND ITS 1,2,4-TRIZOLE DERIVATIVE ON HEPG2 CELL LINE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp524-528, March-2019, Available at : http://www.jetir.org/papers/JETIR1903G77.pdf