• sanjesh kumar g rathi
• Dr shrenik shah
• Dhaval J Patel
• Amar raval
• Asav Goswami

The solid dispersions of Ranolazine with PEG, Poloxamer 407& PVP have been prepared in different weight ratios by using methods like solvent evaporation. Phase solubility studies showed a significant solubilizing effect of all polymers on Ranolazine at different temperatures.FTIR, DSC, and X-ray diffraction spectroscopy were used to characterize the samples of solid dispersions and physical mixture. X-ray powder diffraction and thermal analysis indicated that the drug was present in amorphous form at high concentration of both polymers. FTIR study revealed that the characteristic peaks in spectra of pure Ranolazine are also present in spectra of SDs. Drug found compatible with the excipientsThe highest improvements in solubility and in-vitro drug release were observed in solid dispersion prepared with Poloxamer 407 by solvent evaporation method. The increased dissolution rate of drug from solid dispersion may be due to surface tension lowering effect of polymer to the medium and increased wettability and dispersibility of Ranolazine. Dissolution Efficiency is calculated form DD solver Software and found maximum in S11 batch.Further the prepared tablets using S11 solid dispersion gives maximum dissolution as compared to as such Ranolazine. Additionally S11 give more and fast drug release than the marketed preparation of Ranolazine. These findings are extremely important from a commercial point of view as the prepared solid dispersion removes drawback of poor dissolution profile of Ranolazine.

Ranolazine with PEG, Poloxamer 407, FTIR

"PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION ENHANCEMENT OF RANOLAZINE USING SOLID DISPERSION METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.866-883, March-2019, Available :http://www.jetir.org/papers/JETIR1903H23.pdf

"PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION ENHANCEMENT OF RANOLAZINE USING SOLID DISPERSION METHOD", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp866-883, March-2019, Available at : http://www.jetir.org/papers/JETIR1903H23.pdf