• Pravallika Isukapalli
• R.Rani
• N.Sai deepika
• D.Jahnavi
• Dr.P.Lakshmaiah,Sk.Ahkil

Esomeprazole is a proton pump inhibitor used to treat gastro esophageal reflux disease (GERD) and also used in combination with other medications for preventing stomach ulcers. The buccal mucosa is bordered vertically by the maxillary and mandibular vestibular folds, whereas its anterior and posterior borders are formed by the outer commissural of the lips and the anterior tonsillar pillar, respectively. Additionally there are limited sensory innervations from the facial nerve. The blood supply of the buccal mucosa originates primarily from. Amongst the various routes of drug delivery, oral routes perhaps the most preferred to the patient and the clinician alike. However, per oral administration of drugs has disadvantages such as hepatic first pass metabolism and enzymatic degradation within the GI tract, that prohibit oral administration of certain classes of drugs especially peptides and proteins. Consequently, these advantages include possible bypass of first pass effect, avoidance of presystemic elimination within the GI tract and depending on the particular drug, a better enzymatic flora for drug absorption. The buccoadhesive tablets of Esomeprazole. So, we made an attempt to prepare suitable buccoadhesive system for Esomeprazole to avoid acidic degradation of drug at stomach pH and also to avoid first pass hepatic metabolism. Among all, formulations F4 consists of Esomeprazole (20mg), carbopol (60mg), HPMC (20mg), microcrystalline cellulose (48mg), ethyl cellulose (50mg), magnesium stearate (2mg) was selected as best formulation. Various physiochemical parameters tested for this formulation showed good results. Good correlation was observed between in-vitro and in-vivo drug release profiles. Thus Esomeprazole is suitable candidate for oral controlled drug delivery via buccoadhesive tablets.

Buccal mucosa, Esomeprazole, Tonsillar pillar, enzymatic flora, controlled drug delivery.

"Fabrication and Evaluation of Buccoadhesive Tablets of Esomeprazole", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.344-351, March-2019, Available :http://www.jetir.org/papers/JETIR1903I52.pdf

"Fabrication and Evaluation of Buccoadhesive Tablets of Esomeprazole", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp344-351, March-2019, Available at : http://www.jetir.org/papers/JETIR1903I52.pdf