• Priyanka Joshi
• Dr. Alok Pal Jain
• Dr. Anjana Bhardwaj

For the drugs having dissolution rate limited absorption improvement of aqueous solubility are prerequisite to enhance their therapeutic efficacy. In the present research solid dispersion of slightly aqueous soluble drug Norfloxacin was prepared using mixed hydrotropic solubilization technique. Different blends of sodium citrate, niacinamide and polyethylene glycol 4000 were used used for the preparation of solid dispersion. When Norfloxacin was mixed with Hydrotropic agents blend (1:1:1 of sodium citrate, niacinamide and polyethylene glycol 4000) highest solubility was obtained. Therefore it was selected for further evaluations such as scanning electron microscopy, in vitro dissolution study, differential scanning calorimetry and X ray diffraction analysis. Stability study of mixed hydrotropic solid dispersions also carried out according to ICH guidelines The surface characteristics of solid dispersion showed rough, disordered and intact structures, which subsequently help to dissolve Norfloxacin when comes in contact with aqueous fluid. The X.R.D. pattern of Norfloxacin showed intense and sharp peaks that prove crystalline nature of Norfloxacin. Differential scanning calorimetry indicated complete dispersion of Norfloxacin in the mixture of hydrotropic solvents. In vitro dissolution study indicated fastest drug release from solid dispersion and slowest drug release from bulk Norfloxacin. It was also observed that on increasing the concentration of solubilizing agent dissolution behavior was improved. The quick onset of action and better extent of absorption is expected after oral administration of these hydrotropic solid dispersions due to high initial rate of dissolution from hydrotropic solid dispersion as compared to initial rate of dissolution from bulk drug Norfloxacin alone. Stability studies indicated good chemical stability of all formulations at higher temperature.

Hydrotropic solubilization, Norfloxacin, solid dispersion

"PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF NORFLOXACIN USING MIXED HYDROTROPIC SOLUBILIZATION TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.849-865, March-2019, Available :http://www.jetir.org/papers/JETIR1903K27.pdf

"PREPARATION AND CHARACTERIZATION OF SOLID DISPERSION OF NORFLOXACIN USING MIXED HYDROTROPIC SOLUBILIZATION TECHNIQUE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp849-865, March-2019, Available at : http://www.jetir.org/papers/JETIR1903K27.pdf