• Ab Rouf Wani
• Jahangeer Mohd Reshi

Evaluation of the cytotoxic, antibacterial, and antioxidant properties of various solvent extracts of Viburnum grandiflorum leaves was the primary goal of this research work. The leaves were extracted using the Soxhlet equipment using ethanol, ethyl acetate, n-hexane, and water. To ascertain the extracts' antibacterial activity, the agar well diffusion technique was employed. DPPH scavenging test and hydrogen peroxide reduction technique were used to gauge the antioxidant activity.The cytotoxic studies were carried out by MTT assay using A549 lung cancer cells. Results showed remarkable antibacterial activity of the four extracts against the selected bacteria but higher inhibition and lower MIC values were shown by ethanolic extract with 21.7 ±0.37 mm and 0.1 mg/ml; 29.5 ±0.45 mm and 0.037 mg/ml; 30.5 ± 0.21 mm and 0.07 mg/ml, respectively. The ethanolic extract was the leading one with stronger antioxidant activity and a proliferation inhibition of up to 95% in A549 lung cancer cells, but all the extracts had substantial antioxidant and cytotoxic action in a concentration-dependent manner. As a result, our research revealed that Viburnum grandiflorum leaves had substantial antibacterial, antioxidant, and cytotoxic properties. This suggests that greater attention should be paid to identifying the plant's bioactive components that are responsible for its therapeutic properties.

Viburnum grandiflorum, extract, antioxidant, antibacterial, cytotoxic

"Medicinal Properties of Viburnum grandiflorum leaf extracts growing wild in the Kashmir Himalayas", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.717-723, March-2019, Available :http://www.jetir.org/papers/JETIR1903N94.pdf

"Medicinal Properties of Viburnum grandiflorum leaf extracts growing wild in the Kashmir Himalayas", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp717-723, March-2019, Available at : http://www.jetir.org/papers/JETIR1903N94.pdf