• Patlavath. Babu

The aim of the present study is to develop floating microballons of Imidapril HCl, an oral anti-hypertensive drug and also used in the treatment of chronic heart failure belongs to ACE inhibitor. It is rapidly and completely absorbed from the gastrointestinal tract but having low bioavailability due to first pass metabolism. Single unit dosage form of drug causes gastric irritation and when converted to multiple unit dosage like microballons causes no gastric irritation and maintains a constant drug concentration in the blood plasma for a longer period of time as drug is rapidly absorbed and eliminated from the body. Floating microballons were prepared by non-aqueous solvent evaporation method by using polymers like ethyl cellulose, HPMC and solvents like ethanol, dichloromethane and tween 80. Floating microballons are evaluated for drug entrapment efficiency, percentage yield, floating buoyancy, particle size, shape and surface morphology by SEM and in vitro drug release studies. Results show that as the concentration of polymer increases, the particle size, percentage yield, in vitro buoyancy and drug release from microballons varies. Percentage drug release at the end of 12 hrs was found to be 99.2 % for formulation F2. Microballons that are prepared by HPMC exhibited excellent drug release when compared with ethyl cellulose due hydrophilicity and viscosity. The SEM photographs revealed that the formulated floating Microballons were spherical in shape, smooth textured and having 500 µm sizes.

Ethyl Cellulose, Floating Microballons, Hydroxy Propyl Methyl Cellulose (HPMC), Imidapril HCl.

"FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING MICROBALLOONS OF IMIDAPRIL HCl", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.257-263, March-2019, Available :http://www.jetir.org/papers/JETIR1903O39.pdf

"FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING MICROBALLOONS OF IMIDAPRIL HCl", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp257-263, March-2019, Available at : http://www.jetir.org/papers/JETIR1903O39.pdf