• Prapulla Putta
• Prof (Dr) Kaushal K. Chandrul

In the current research the title Benzofuran are synthesized from methyl-2-hydroxy benzoate which has been nitrated at 5-positon by concentrated sulphuric acid and nitric acid further prepared methyl-2-hydroxy-5-nitro benzoate. Benzofuran are synthesized from methyl-2-hydroxy benzoate which has been nitrated at 5-positon by concentrated sulphuric acid and nitric acid further prepared methyl-2-hydroxy-5-nitro benzoate. The prepared methyl-2-hydroxy-5-nitro benzoate was converted to basic environment by freshly prepared Chloroacetyl chloride to form [2-(3-hydroxy-5-nitro-1-benzofuran-2-carbabonyl) hydrazinyl] acetyl chloride which is further undergoes cyclisation and yielded N-(5-amino-2, 5-dihydro-1, 3-thiazol-2-yl)-3-hydroxy-5-nitro-1-benzofuran-2-carbohydrazide. Then it was reacted with acetaldehyde which yielded the title compound N-(5-ethylamino) -2, 5-dihydro-1, 3-thiazol-2-yl)-3-hydroxy-5- nitro-1-benzofuran-2-carbohydrazide. To prepare further derivatives the hydroxyl group in the different position has been treated with reagents which had underwent the substitution chlorine at position 3 and yielded different alkyl and aryl amine carbohydrazide derivatives.

Benzofuran, Carbohydrazide, Heterocyclic.

"SYNTHESIS AND EVALUATION OF N-(5-ETHYL AMINO) -2, 5-DIHYDRO-1, 3-THIAZOL-2-YL)-3-HYDROXY-5-NITRO-1-BENZOFURAN-2 CARBOHYDRAZIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.613-619, March-2019, Available :http://www.jetir.org/papers/JETIR1903O84.pdf

"SYNTHESIS AND EVALUATION OF N-(5-ETHYL AMINO) -2, 5-DIHYDRO-1, 3-THIAZOL-2-YL)-3-HYDROXY-5-NITRO-1-BENZOFURAN-2 CARBOHYDRAZIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp613-619, March-2019, Available at : http://www.jetir.org/papers/JETIR1903O84.pdf