• Lenkalapally Matsyagiri
• Prof (Dr) Kaushal K. Chandrul

The present investigation deals with the development and evaluation of floating microballoons of Piretanide to extend the gastric residence time (GRT) and prolong the drug release. In the present work, floating microballoons of Piretanide were formulated using Eudragit RS 100, Eudragit S 100, and HPMC K4M and ethyl cellulose polymers by the solvent evaporation method. The prepared microballoons were evaluated for their physicochemical properties, in-vitro drug release, and in-vitro buoyancy. The in-vitro release studies demonstrated that microballoons of Piretanide prepared using Eudragit RS 100 along with Eudragit S 100 in 1:1 ratio (PRTF10) shown the maximum amount of drug release; hence it is considered as the optimized formulation. The in-vitro release kinetics revealed that the optimized formulation releases the drug in zero-order manner based on the regression values of kinetic models.

Eudragit S 100, Eudragit RS 100, Ethyl Cellulose, Floating Microballons, Hydroxy Propyl Methyl Cellulose (HPMC), Piretanide.

"FORMULATION AND IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING MICROBALLOONS OF PIRENTANIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 3, page no.620-630, March-2019, Available :http://www.jetir.org/papers/JETIR1903O85.pdf

"FORMULATION AND IN VITRO EVALUATION OF GASTRO RETENTIVE FLOATING MICROBALLOONS OF PIRENTANIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 3, page no. pp620-630, March-2019, Available at : http://www.jetir.org/papers/JETIR1903O85.pdf