• Priyanka Bisht
• Ashutosh Badola

The goal of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to promptly achieve and to maintain the desired drug concentration. Delivery of drugs through the skin has been an attractive as well as challenging area for the research. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. Topical application of drugs offers potential advantages of delivering the drug directly to the site of action and acting for an extended period of time. There are different semisolid dosage forms that are used for topical application among which gel formulations are becoming pre-eminent. A gel is colloid that is typically 99% by weight liquid, which is immobilized by surface tension between it and a macromolecular network of fibres built from a small amount of a gelatinous substance present. The basic network of gel is a combination of a gelling agent and a solvent in which the drug molecules are embedded or entwined evenly. Gels have better potential as a vehicle to administered drug topically in comparison to other topical dosage form because they are non-sticky requires low energy during the formation. This review highlights the basic advantages of gel formulations over other semisolid preparations as well as limitations of their use. Other aspects such as their classification, formulation, mechanism involved in the formation of gels and factors affecting their formulations have been included.

Topical drug delivery, semisolid dosage form, gelling agents, topical gel

"GEL AS A TOPICAL DRUG DELIVERY SYSTEM: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.321-330, April-2019, Available :http://www.jetir.org/papers/JETIR1904048.pdf

"GEL AS A TOPICAL DRUG DELIVERY SYSTEM: A REVIEW", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp321-330, April-2019, Available at : http://www.jetir.org/papers/JETIR1904048.pdf