• Payal Rani

Click Chemistry concept was introduced by K.B. Sharpless in 2001 which is similar to rapidly assembling of very small building blocks collectively to make a huge structure. “Click” refers to strongly favored, versatile and specific chemical change, which lead to a single reaction product. It is just a term used for a class of reaction that can create very complex molecules in an efficient manner with a higher yield of product. This paper is all about the Cu catalyzed azide-alkyne cycloaddition reaction (CuAAC) leads to the formation of triazoles. It was found that this chemistry uses only the reliable reaction to make complex from electrophiles, olefins and heteroatom linkers. These are found to be high yielding, stereospecific and simple to perform reactions. For these click reactions, the reaction condition should be mild and insensitive to oxygen and water. Cycloaddition of azides and alkyne in the presence of Cu as a catalyst is the most powerful example of click chemistry. The product triazoles formed in the reaction found to exhibit anti-HIV, antibacterial, anticancer activities. 

Click Chemistry, Click reaction, Cu catalysed Azide-Alkyne Cycloaddition, Pharmocological application of Click Reaction

"Cu Catalyzed Azide-Alkyne Cycloaddition with Pharmacological Applications of Click Chemistry", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.419-422, April-2019, Available :http://www.jetir.org/papers/JETIR1904060.pdf

"Cu Catalyzed Azide-Alkyne Cycloaddition with Pharmacological Applications of Click Chemistry", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp419-422, April-2019, Available at : http://www.jetir.org/papers/JETIR1904060.pdf