• Parth Patel
• Dr. Shrenik Shah
• Dipal Patel

The present work aimed to formulate and evaluate sustained release floating tablets of captopril and hydrochlorothiazide. The development was started by using direct compression method for process ease. Different rate controlling polymers were selected for initial screening. HPMC K4M, HPMC K100M and Sodium alginate checked for initial primary screening. Drug release of tablets well controlled by the HPMC K100M polymers were another twp polymers are not able to sustained the drug in matrix form and release earlier. Hence the rate controlling polymer HPMC K100M selected and further development done for floating behavior followed by diluent screening. The best combination of Sodium bicarbonate and citric acid optimized. Preformulation study revealed that the drugs were found with the selected excipients. F1-F17 batch developed and physical as well as chemical analysis were done for all batches. Further, formulation F16 found stable during stability study. Hence, F16 formulation optimized. Floating lag time of this batch has only 17 sec and tablet float for more than 12 hours. So, it is suitable for our formulation. So, finally obtained batch F16 which is suitable for our experiment have 30 mg HPMC K100M, 20 mg Sodium bicarbonate, 114 mg DCP and required quantity of glidant and lubricant.

Captopril, Hydrochlorothiazide, Floating, Sustained release

"FORMULATION AND EVALUATION OF GASTRIC FLOATING TABLETS CONTAINING CAPTOPRIL AND HYDROCHLOROTHIAZIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.6, Issue 4, page no.509-523, April-2019, Available :http://www.jetir.org/papers/JETIR1904071.pdf

"FORMULATION AND EVALUATION OF GASTRIC FLOATING TABLETS CONTAINING CAPTOPRIL AND HYDROCHLOROTHIAZIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.6, Issue 4, page no. pp509-523, April-2019, Available at : http://www.jetir.org/papers/JETIR1904071.pdf